| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1721d75f5bf603447ec5a26b5c1c0be0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4d5de9a1dac6b033c4643bb236ef4df3 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-475
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-118
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-347 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6893
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-37
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-675 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-675
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N- |
| filingDate |
2004-03-26^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a2be2d284418e780ec3a774461ba6269
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a6ccb5ab97c19d94eadc24ace223d1f |
| publicationDate |
2019-08-20^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
BR-PI0408802-B1 |
| titleOfInvention |
METHOD FOR DETECTION OF ISCHEMICAL RENAL TUBULAR CELL INJURY AND METHOD TO IDENTIFY EXTENSION OF THIS INJURY |
| abstract |
"Method and kit for detecting early onset of renal tubular cell injury". The present invention relates to a method and kit for detecting early onset of renal tubular cell injury using ngal as an early urinary biomarker. ngal is a small secreted polypeptide that is protease resistant and consequently readily detected in the urine following renal tubule cell damage. ngal protein expression is detected predominantly in proximal tubule cells in a dotted cytoplasmic distribution reminiscent of a secreted protein. The appearance of ngal in the urine is related to the dose and duration of renal ischemia and nephrotoxemia, and is a diagnosis of renal tubule cell damage and renal failure. ngal detection is also a useful marker for monitoring nephrotoxic side effects of drugs or other therapeutic agents. |
| priorityDate |
2003-03-27^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |