| abstract |
DERIVATIVES OF 2,4-DIANILINE PYRIMIDINES, THE RESPECTIVE PREPARATION, BY TITLE OF MEDICINES, PHARMACEUTICAL COMPOSITIONS AND NOTELY AS IKK INHIBITORS. The present invention relates to the products of formula (1), in which R2, R3 and R $ represent a hydrogen and the others hydrogen, halogen, alkyl or alkoxy; R5 represents hydrogen or halogen; R1 represents hydrogen, cycloalkyl, alkyl, alkenyl or alkynyl, all eventually substituted; A represents simple bonding or -CH2-CO-NR6- with R6 is chosen from the values of R1; the cycle containing Y (or cycle (Y) having 4 to 8 chains with Y represents O, S, SO, SO2, N-R7 (cycle Y) which may contain a carbon bridge), C = O or its dioxolane, CF2 , CH-OR8, CH-NR8R9; and R7 represents hydrogen, cycloalkyl, alkyl, CH2-alkenyl or CH2-alkynyl, optionally substituted; R8 represents hydrogen, alkyl, cycloalkyl or heterocycloalkyl which may be substituted, - these products of formula (1) being in all isomeric forms and the title salts of drugs, notably as IKK inhibitors. |