| abstract |
PROTEIN KINASE INHIBITORS, COMPOSITIONS CONTAINING THE SAME WELL AS THEIR USES. The present invention relates to novel pyrimidine and pyridine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine and pyridine derivatives of the invention may be used to treat, ameliorate or prevent a condition that responds to inhibition of anaplastic lymphoma kinase (ALK) activity, focal adhesion kinase (FAK) activity, protein kinase 70-associated activity. zeta chain (ZAP-70), insulin-like growth factor (IGF-1 R), or a combination thereof. |