| abstract |
compound, pharmaceutical composition, and method to activate the 5'-amp activated protein kinase pathway in a cell are exposed carboxamide compounds, as well as pharmaceutical compositions and methods of use. one embodiment consists of a compound having the structure, in which r1, r2, r3, r4, d, j, z, t, p, q, w and x are as described herein. in certain embodiments, a compound described herein activates the ampk pathway, and can be used for the treatment of disorders and conditions related to metabolism. |