| abstract |
COMPOSITIONS BASED ON PREPOLIS NANOParticles, OBTAINING AND USE PROCESSES. The present invention relates to the process of obtaining and using compositions consisting of propolis nanoparticles, optionally associated with one or more substances of interest, such as active ingredients, as well as, optionally, side effect substances, such as synergists and The process for obtaining the nanoparticles comprises the following steps: i) preparation of: a fraction A consisting of propolis extract dissolved in organic solvent to which one or more stabilizers and / or emulsifiers may be added as well as added optionally one or more substances of interest and / or side effect; ii) preparation of a fraction B, aqueous phase, consisting of: (ii. 1) water; or (ii.2) an aqueous solution or dispersion to which one or more stabilizers and / or emulsifiers may be added; iii) dripping of fraction A over fraction B or fraction B into fraction A; iv) homogenization of the mixture by mechanical stirring and spontaneous formation of nanoparticles with an average size of 1 to 1000 nm in a dispersion; v) optionally, the following additional steps may be involved: (v-1) removal of the organic solvent; and / or (v-2) drying the nanodispersion. The compositions developed have applications in fields such as agrochemical, cosmetic pharmaceutical or chemical. |