| abstract |
naphthalene carboxamide derivatives as protein kinase and histone deacetylase inhibitors, methods of preparation and uses. naphthalene carboxamide derivatives, methods of preparation and uses thereof are provided. their structure is shown as formula (1), when the definitions of r1, r2, r3, d4 and z are the same as described in the description. the compounds have protein kinase inhibiting activities and histone deacetylase inhibiting activities simultaneously, and can be used to treat diseases associated with abnormal protein kinase activity or abnormal history deacetylase activity, including inflammation, autoimmune diseases, cancer, liver diseases. nervous system and neurodegenerative diseases, cardiovascular diseases and metabolic diseases, allergic asthma and hormone-related diseases. |