| abstract |
ABSTRACT OF THE DISCLOSURE Acetic acid derivatives having the general formula: (I) and their pharmaceutically acceptable alkali metal salts, wherein R represents a radical of the formula: or in which R1 and R2 are the same or different and each represent an alkyl radical having from 1 to 4 carbon atoms, R3 represents a hydrogen atom or a methyl radical and n is an integer in the range of from 0 to 3 inclusive. These compounds exhibit a competitive inhibitory activity with respect to ?-aminobutyric .alpha.-ketoglutaric transaminase and antianoxic and anticonvulsant actions and can thus be utilized for the treatment of central neurological dis-orders whether resulting or not from cerebral ischemia. |