http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-1268174-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5929f2d6f4dba84be8dd3a8ba633db12 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-06 |
| filingDate | 1986-06-03^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1990-04-24^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f2d35660ec32e359b1cb487ea1946b2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9d8c69c706ffd321f128eb629445d5a6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fb00f7d504d05b0a13f99f103010d175 |
| publicationDate | 1990-04-24^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-1268174-A |
| titleOfInvention | Conversion of uracil derivatives to cytosine derivatives |
| abstract | Abstract of the Disclosure A process is disclosed for producing a 4-0-sulfonyi-uracil derivative of the formula [wherein R1 is hydrogen, halogen, alkyl and alkoxy, R2 is glycosyl having protected hydroxyls; and -SO2R3 is an organic sulfonyl] which comprises reacting an uracil derivative of the formula [wherein R1 and R2 are the same above] with an organic sulfonylating agent of the formula R3 SO2X [wherein R3SO2 is an organic sulfonyl and X is halogen] in the presence of potassium carbonate. The obtained 4-0-sulfonyluracil is further subjected to amination. The processes are industrially advantageous and produce cytosine derivatives such as cytidine in high yield. The 4-0-sulfonyluracil derivative is useful as an intermediate for production of drugs such as cytidine diphosphate choline whose generic name is Citicoline. |
| priorityDate | 1985-06-04^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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