http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-1334174-C
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d12fcf94a35348198bf31558dcff2cf6 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00 |
| filingDate | 1989-04-25^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1995-01-31^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bd9ef25c0cd976abff70ca477c9980cd |
| publicationDate | 1995-01-31^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-1334174-C |
| titleOfInvention | 2- and 8-azido (2'-5')oligoadenylates and antiviral uses thereof |
| abstract | Compounds of the formula wherein m is 0, 1, 2 or 3; n is 0, 1, 2 or 3; and each R1 and each R2 is, independently of each other R1 and R2, hydrogen or N3, provided at least one R1 or R2 is N3; and water soluble salts thereof. Compounds of the formula activate RNase L, leading to the cleavage of viral mRNA or rRNA, thereby inhibiting viral protein synthesis. They also have activity against plant-infecting viruses. The compounds, upon UV irradiation, form nitrene free radical intermediates which are capable of covalently photoinsert-ing into (or cross-linking) biological molecules. |
| priorityDate | 1988-04-26^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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