| abstract |
A novel hexa-cyclic compound, a derivative of camptothecin, of the general formula: (see formula I) The compound is prepared from an aminoketone compound and a pyranoindolizine compound by a condensation-ring closing reaction. It is abundantly water-soluble, and has an excellent antitumour activity and a high degree of safety, and can be applied as an antitumour medicine for curing tumors of various kinds. |