| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c26895e1df2ffdb5a7a07dc40911694c |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02E50-10 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-252
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D203-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-048
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0036
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y101-01284
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C219-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C271-18 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-01
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-07 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-048
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C219-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D203-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-573
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-252
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-53 |
| filingDate |
1992-10-23^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e3b9d0d87f4a5b8e795adf683c195d5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_869285969171c4aa00322bb2fc873892
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_be98f877791d0b2471c7021ae172e0dd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3ecd2aa9b698ae97aacbdd2161baa6bf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_54b5abdb2b8559a801e4c885e5bc7854
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e9f750cb07ee3a25dc08a874234f278
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1ec669615a068b8e0322a1c1c0f86bcb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bf31240b995ce40003de8dd2f79cbcb0 |
| publicationDate |
1993-04-29^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CA-2122036-A1 |
| titleOfInvention |
Bacterial nitroreductase for the reduction of cb 1954 and analogues thereof to a cytotoxic form |
| abstract |
The invention provides a nitroreductase, obtainable from a bacterium having the following characteristics as exemplified by examples isolated from Escherichia coli B and Bacillus amyloliquifaciens: 1) it is flavoprotein having a molecular weight in therange 20-60 Kilodaltons; 2) it requires either NADH or NAD(P)H or analogues thereof as a cofactor; 3) it has a Km for NADH or NAD(P)H in the range 1-100 µM; and 4) it incapable of reducing either of both nitro groups of CB 1954 and ana-logues thereof to a cytotoxic form e.g. the hydroxylamine. The sequence of one such nitroreductase is shown in Seq. ID No. 1. The nitroreductase maybe conjugated to a tumour targeting agent such as a monoclonal antibody and used to convert prodrugs into active antitumour agents. Such prodrugs and drugs are also provided. |
| priorityDate |
1991-10-23^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |