| abstract |
HOECHST AKTIENGESELLSCHAFT - HOE 93/F 223 K Dr.VF/we Abstract Benzo-fused heterocyclic compounds having a 5-membered ring, processes for their preparation, their use as medicaments, their use as diagnostic agents and medica-ments containing them Benzo-fused heterocyclic compounds having a 5-membered ring, of the formula I (I) where X is N or CR(6); Y is oxygen, S or NR(7); A and B together are a bond or are both hydrogen, if, at the same time, X is CR(6) and Y is NR(7), one of the substituents R(1) to R(6) is a -CO-N=C(NR2)2 group; the other respective substituents R(1) to R(6) are H, Hal or alkyl; up to two of the other substituents R(1) to R(6) are CN, N02, N3, (C1-C4)-alkoxy, CF3; up to one of the other substituents is R(8)-CnH2n-Z- or phenyl; R(7) is H, alk(en)yl or R(8)-CnH2n-, and pharmaceutically tolerated salts thereof, are described. A process for the preparation of the compounds I which comprises reacting a compound of the formula II (II) in which one of the substituents R(1)' to R(5)' is a -CO-L group and L is a leaving group which can easily be replaced nucleophilically, with guanidine, and, if appropriate, converting the product into the pharmaco-logically tolerated salt, furthermore is also described. |