http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2153627-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_32fc7f4a32d5ae7c49f51c0b48ec3d7c http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_51c8021610607a5820ee00a5c9bbb629 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_185cf44ea3dcc585d9bd54070184d1d6 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N27-333 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12M1-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-37 |
| filingDate | 1995-07-11^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1004c4b5078d1c0cd7a9dd33bfdbb212 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a9a018f61a5a56d91c417565b0fbf89 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_309049da9dccb0d033b3cc95b6afdae7 |
| publicationDate | 1996-12-08^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2153627-A1 |
| titleOfInvention | Protamine-responsive polymeric membrane electrode |
| abstract | A polymeric membrane electrode gives potentiometric responses to macromole-cules, such as protamine, in solution or biological specimens. A protamine-responsive membrane includes a lipophilic cation-exchange material for ionic macromolecules in a specially formulated plasticized, polymeric matrix material. Potentiometric response to protamine has been observed in membranes comprising 30-70 wt.% polymeric matrix material, such as polyvinyl chloride; 1-3 wt.% salt of a tetraphenylborate, such as potassium tetrakis(4-chlorophenyl) borate or salt of an organophosph(on)ate, such as calcium bis-[4-(1,1,3,3-tetramethylbutyl)phenyl] phosphate; and 30-70 wt.% of a plasti-cizer, such as 2-nitrophenyl octyl ether or tris (2-ethylhexyl) phosphate. The potentio-metric response of these membranes to protamine can be used to study the binding inter-action of protamine with heparin (both native and low molecular fractions) or to monitor protease activity, for example, by following the rate of degradation of intact protamine or a synthetic substrate by trypsin, as well as to measure protamine concentration in bio-logical fluids, such as blood or plasma. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114019005-A |
| priorityDate | 1995-06-07^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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