abstract |
A process of preparing thalidomide in which N- phthaloylglutamine or N-phthaloylisoglutamine is cyclized with N,N'-carbonyldiimidazole, characterised in that the process comprises heating said N-phthaloylglutamine or N- phthaloylisoglutamine and N,N'-carbonyldiimidazole in refluxing anhydrous tetrahydrofuran. |