| abstract |
A compound of structural Formula (1) or pharmaceutically acceptable salts thereof wherein: R is -C(O)-R1, -PO3= or -P(O)(OH)2; R1 is C1-6 alkyl, -N(R4)2, C1-6 alkyl-N(R4)2, -phenyl-N(R4)2, -phenyl- NHC(O)CH2NH2,-C2H4-morpholinyl, pyridinyl, C1-6 alkyl-OH, C1-6 alkyl-OCH3, C1-6 alkyl C(O)CH3, -O-C1-6 alkyl-OCH3, C0-3 alkyl-piperazinyl (optionally substituted with C1-3 alkyl), imidazolyl, C1-6 alkyl-COOH, -C(CH2OH)2CH3; R2 and R3 are independently selected from hydroge n or F except at least one of R2 or R3 is F; R4 are independently selected from hydrogen or C1-6 alkyl. The compounds are water soluble and are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including multiply-resistant staphylococci, enterococci and streptococci, as well as anaerobic organisms such as bacteriodes and clostridia species, and acid-fast organism s such as Mycobacterium tuberculosis. |