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filingDate 1995-04-27^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_42f670a8809130bc5ad598c7acd08bc9
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publicationDate 1995-11-09^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CA-2189050-A1
titleOfInvention Method for detecting free igfbp-1
abstract A method and device is described for detecting fetal membrane rupture by detecting only that insulin-like growth factor-binding protein 1 (IGFBP-1) which is free of insulinlike growth factors 1 and 2 (IGF-1 and IGF-2). The method is based on the fact that the concentration of free IGFBP-1 in the blood serum is about ten times lower than that of the IGFBP-1 bound to IGF-1 and IGF-2, while the amniotic liquid which is contained in the amnion has more than 1000 times the concentration of free IGFBP-1 than the blood serum. The device comprises a one pad (22) and two strips (24, 26) test kit which may be used to detect free IGFBP-1 in a range of concentrations from 5 ng/ml to 250 .mu.g/ml.
priorityDate 1994-04-28^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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