http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2195757-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1c89ce4d9ac03f9acd8ddede1162f94d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-10 |
| filingDate | 1995-08-07^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e0fb5b4225f5fa17d6a1e74e5fe4580 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d93739b5ab79e3a579c19d6da88eaea http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d6ebbbc35f3a8e599c65f44841c3c4c6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ac5083be80b55ca8f72ee5dba8c8165 |
| publicationDate | 1996-02-22^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2195757-A1 |
| titleOfInvention | Spiro-substituted azacyclic derivatives and their use as therapeutic agents |
| abstract | The present invention relates to compounds of formula (I), wherein n is zero, 1, 2 or 3; R represents C1-6alkyl, C1-6alkoxy, hydroxy, halogen, cyano, trifluoromethyl, SO2C1-6alkyl, NR a R b, NR a COR b or CONR a R b, where R a and R b are each H, C1-6alkyl, phenyl or trifluoromethyl; R1 represents phenyl optionally substituted by 1, 2 or 3 of C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-7cycloalkyl, C3-7cycloalkylC1-4alkyl, -O(CH2)p O- (where p is 1 or 2), halogen, cyano, nitro, trifluoromethyl, trimethylsilyl, OR a, SR a, SOR a, SO2R a, NR a R b, NR a COR b, NR a CO2R b, COR a, CO2R a or CONR a R b; naphthyl; benzhydryl: or benzyl, where the naphthyl group or each phenyl moiety of benzyl and benzhydryl may be substituted by C1-6alkyl, C1-6alkoxy, halogen or trifluoromethyl; R2 represents hydrogen, a substituent as defined for R1 or heteroaryl selected from indazolyl, thienyl, furanyl, pyridyl, thiazolyl, tetrazolyl and quinolinyl; wherein each heteroaryl may be substituted by C1-6alkyl, C1-6alkoxy, halogen or trifluoromethyl; R3 and R4 are each H or C1--6alkyl or R3 and R4 together are linked so as to form a C1-3alkylene chain; R5 represents H, C1-6alkyl, C3-7cycloalkyl, C3-7cycloalkylC1-4alkyl, phenylC1-4alkyl, CO2R a, CONR a R b, SOR a or SO2R a, wherein the phenyl moiety may be substituted by C1-6alkyl, C1-6alkoxy, halogen or trifluoromethyl; X and Y are each H, or together represent =O; and Z represents a bond, O, S, SO, SO2, NR6, or -(CR6R6)- where R6 is H or C1-6alkyl; or a pharmaceutically acceptable salt thereof. The compounds are of particular use in the treatment or prevention of pain, inflammation, migraine, emesis and postherpetic neuralgia. |
| priorityDate | 1994-08-08^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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