http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2219278-C
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_05ff905fdc49089f5f25746eaeb40190 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-27 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C235-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-05 |
| filingDate | 1996-04-26^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2006-06-13^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e889da4b5d2edff58e1f5d51c566335d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_713613da1f531dbdc11505783b25a555 |
| publicationDate | 2006-06-13^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2219278-C |
| titleOfInvention | Methods of making (s)-3-(aminomethyl)-5-methylhexanoic acid |
| abstract | The present invention provides a method of making (S)-(+)-3-(aminomethyl)-5- methylhexanoic acid which comprises condensing isovaleraldehyde with an alkyl cyanoacetate to form a 2-cyano-5-methylhex-2- enoic acid alkyl ester, reacting the 2-cyano-5-methylhex-2-enoic acid alkyl ester with a dialkyl malonate to form 3- isobutylglutaric acid; forming the anhydride of 3-isobutylglutaric acid; reacting the anhydride with ammonia to form (~)-3-(carbamoylmethyl)-5-methylhexanoic acid' reacting (t)-3-(carbamoylmethyl)-5-methylhexanoic acid with (R)-(+)-.alpha.-phenylethylamine to obtain the (R)-(+)-.alpha.- phenylethylamine salt of (R)-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid; combining the salt with an acid to obtain (R)-(-)-3-(carbamoylmethyl)-5- methylhexanoic acid' and reacting the (R)-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid with a Hofmann reagent to obtain (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid. |
| priorityDate | 1995-06-02^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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