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filingDate 2000-10-06^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2012-07-03^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_79cd1991bdd4b0d7bd3f575d045581cb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_70666be4fdfeb04e83ca607e15a10761
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publicationDate 2012-07-03^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CA-2397610-C
titleOfInvention In vivo assay for testing the phenotypic stability
abstract An in vivo assay to measure anchorage-independent growth and phenotypic stability of a certain cell population comprising subcutaneous or intramuscular injection in a mammal of a cell suspension of articular chondrocytes in an iso-osmotic liquid, the same suspension comprising articular chondrocytes in an amount equivalent to at least 1 x 106 chondrocytes as applied to immune-deficient mice. The outcome is linked to molecular markers. The present invention further relates to DNA chips and diagnostic tools comprising the latter to predict the outcome of ACT. Antibodies raised against positive and negative markers of chondrocyte stability can also be used for quality control on the chondrocytes. Therapeutical composition comprising stable chondrocytes are very useful for tissue repair.
priorityDate 1999-10-06^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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