| abstract |
Compounds of the formula (I) (see formula I) or a pharmaceutically acceptable salt or isomer thereof, wherein: Q, X and Z are CH or N; R, R4-R7 and R13 are H or alkyl; R1 is H, alkyl, fluoroalkyl, R9-arylalkyl, R9-heteroarylalkyl, alkyl-SO2-, cycloalkyl-SO2-, fluoroalkyl-SO2-, R9-aryl-SO2-, R9-heteroaryl-SO2-, N(R22)(R23)-SO2-, alkyl-C(O)-, cycloalkyl-C(O)-, fluoroalkyl-C(O)-, R9-arylC(O)-, NH-alkyl-C(O)- or R9-aryl-NH-C(O)-; R2 is H and R3 is H, alkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, R9-aryl, R9-arylalkyl, R9heteroaryl, or R9-heteroarylalkyl, and when X and Z are each CH, R3 is alkoxy, R9-aryloxy, R9-heteroaryloxy, alkylC(O)O-, alkylaminoC(O)O-, alkylC(O)NR13-, alkylOC(O)NR13-- or alkylaminoC(O)NR13-; or R2 and R3 together are = O, = NOR10, = N-NR11R12 or = CH-alkyl; R8 is substituted phenyl, substituted heteroaryl, naphthyl, fluorenyl, diphenymethyl, alpha-substituted benzyl or alpha-substituted heteroarylmethyl; are as defined; are disclosed for the treatment of HIV, solid organ transplant rejection, graft v. host disease, inflammatory diseases, atopic dermatitis, asthma, allergies or multiple sclerosis, as well as pharmaceutical compositions and combinations with antiviral or anti-inflammatory agents. |