| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2643904cd5a6af4ec2c1c76442d36a24 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2795-10022
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-01 |
| filingDate |
2004-02-06^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_18c6988a52fdacd7f3148d398752cd09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a5502cee06d6709e4f8887bffea653f8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f38daf13d96ab62c6e56df22922e320d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1816df2b84575770d79ee008f3ac56ef
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_03b29c2f5ddd825176da7bf8fb890f0c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_38a70cd7a651c52819a1d235dc29c05c |
| publicationDate |
2004-08-07^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CA-2457220-A1 |
| titleOfInvention |
Inhibitors of staphylococcus aureus primary sigma factor and uses thereof |
| abstract |
The present invention discloses inhibitors of the primary sigma factor in Staphylococcus aureus (.sigma.SA), an essential protein implicated in RNA synthesis. The invention also discloses methods for inhibiting bacterial growth by contacting a bacterium with an antibacterial compound that specifically binds to a bacteriophage polypeptide binding domain of the Staphylococcus aureus primary sigma factor. Examples of inhibitors include bacteriophage polypeptides inhibiting growth of S. aureus and bacteriophage polypeptides binding specifically to S. aureus primary sigma factor. In addition, the invention discloses screening methods for identifying compounds which inhibit biochemical and/or cellular activity of S. aureus primary sigma factor. |
| priorityDate |
2003-02-07^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |