| abstract |
A compound represented by the formula (I) [wherein Ar represents an optional ly substituted cyclic group; X represents a bond or a spacer having a C1-6 main chain; R1 and R2 are the same or different and each represents hydrogen or a n optionally substituted hydrocarbon group or R1 and R2 may form an optionally substituted nitrogenous heterocycle in cooperation with the adjacent nitroge n atom; Y represents an optionally substituted divalent hydrocarbon group (excluding CO); R3 represents hydrogen or an optionally substituted hydrocarbon group; and ring A and ring B each may have other substituent(s), and when ring B has another substituent, then this substituent may be bonded to R1 to form a ring]; a salt of the compound; or a prodrug of any of these. They have antagonistic activity against a melanin-concentrating hormone and hence are useful as an obesity preventive/remedy, etc. |