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filingDate 2003-08-08^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2012-04-17^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_def43ae1b243d426de80fb8f894ade64
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publicationDate 2012-04-17^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CA-2494987-C
titleOfInvention Isoxazoles and their use as modulators of metabotropic glutamate receptor-5
abstract The present invention relates to new compounds of formula (I), a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy. In particular, there are compounds according to the present invention that are potent and selective for the mGluR Group I receptor and more particularly for mGluR5. Thus, it is expected that the compounds of the invention are well suited for the prevention and/or treatment of mGluR5 receptor-mediated disorders such as acute and chronic neurological and psychiatric disorders and chronic and acute pain disorders.
priorityDate 2002-08-09^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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