| abstract |
Compounds of formula (I) wherein R is hydrogen, lower alkyl, (C3- C8)cycloalkyl, hydroxy, halo, lower alkoxy, trifluoromethoxy, trifluoromethy l or cyano; and A is biaryl, optionally substituted .beta.-naphthyl, bicyclic heterocyclic aryl, (C3-C6)cycloalkylmonocyclic carbocyclic aryl, or (C5 or C6)cycloalkane fused-monocyclic carbocyclic aryl; pharmaceutically acceptabl e salts thereof, and pharmaceutically acceptable esters thereof; which are useful for the treatment of COX-2 dependent disorders. |