| abstract |
The present invention provides pyrazole derivatives represented by the general formula: (see formula I) wherein R1 represents H, an optionally substituted C1-6 alkyl, etc. ; one of Q and T represents a group selected from the following: (see formula II, III, IV, V, VI) and the other represents -Z-Ar wherein Z represents -O-, -S-, etc.; Ar represents an optionally substituted C6-10 aryl, etc.; R represents an optionally substituted C3-8 cycloalkyl, an optionally substituted C6-10 aryl, etc., pharmaceutically acceptable salts thereof, and prodrugs thereof, which exhibit an excellent inhibitory activity in human sodium/glucose cotransporter (SGLT) and are useful as agents for the prevention, inhibition of progression or treatment of a disease associated with the excess uptake of at least a kind of carbohydrates selected from glucose, fructose and mannose (diabetes, postprandial hyperglycemia, impaired glucose tolerance, diabetic complications, etc.), and pharmaceutical compositions containing the same, medicinal uses thereof and intermediates for production therefor. |