| abstract |
The present invention relates to protein biocoacervates and biomaterials comprising an amorphous body that is crosslinked and includes aggregated complexes having homogenously distributed biocoacervated components, the components including one or more soluble or solubilized primary proteins combined with one or more glycosaminoglycans and one or more biocompatible solvents. The present invention further relates to methods of making the biocoacervates and biomaterials and methods of using the biocoacervates and biomaterials for various medical applications including, but not limited to, drug delivery devices for the controlled release of pharmacologically active agents, coated medical devices (e.g. stents, valves . . . ), vessels, tubular grafts, vascular grafts, wound healing devices including protein suture biomaterials and biomeshes, dental plugs and implants, skin/bone/tissue grafts, tissue fillers, protein biomaterial adhesion prevention barriers, cell scaffolding and other biocompatible biocoacervate or biomaterial devices. |