| abstract |
The invention relates to the products of formula (I): with X-Y is NH-C (S), N = C-NR7R8, N = C-SR, N = C-R or N = C-OR; R and R1 represents H, cycloalkyl, alkyl, heterocycloalkyl, aryl or heteroaryl, optionally substituted; R2 represents H, Hal or alkyl; R3 represents H, Hal, OH, alkyl or alkoxy; R4 is H, Hal, CN or alkyl; R5 is in particular H, Hal, OH, NR7R8, cycloalkyl, alkyl, alkoxy, heterocycloalkyl, aryl or heteroaryl, optionally substituted; R6 is H, Hal, OH, NH2, NHalk, N (alk) 2, alkyl or alkoxy; with R7 and R8 such that one represents H or optionally substituted alk; and the other is H, cycloalkyl, alkyl, heterocycloalkyl, heteroaryl or aryl, optionally substituted; or R7 and R8 together with N form a cyclic radical, optionally containing O, S or N, optionally substituted; their isomers and their salts, as medicaments in particular as inhibitors of kinases and particularly of CDC7. |