| abstract |
Disclosed is a method for producing an oxazoline derivative from a non-pr otected sugar in a simple manner. Also disclosed is a method for producing a glycoside by utilizing the product of the aforementioned method. A sugar ox azoline derivative is synthesized in one step in an aqueous solution from a sugar having a free hemiacetal hydroxy group and an amide group by using a h aloformamidinium derivative as a dehydration/condensation agent. A glycoside is produced by using the oxazolidine derivative as a sugar donor and also u sing a sugar dehydrogenase. The method can be applied to the production of a compound having a long sugar chain, and is therefore useful for the product ion of a physiologically active oligosaccharide, a carrier for a drug delive ry system, a surfactant, a carbohydrate pharmaceutical, a glycopeptide, a gl ycoprotein, a carbohydrate polymer or the like. |