| abstract |
The present invention relates to compounds of formula wherein Ar1 and Ar2 are independently from each other unsubstituted or substituted aryl or heteroaryl; R1/R2 are independently from each other hydrogen, lower alkyl, lower alkyl substituted by halogen, -(CH2)o-O-lower alkyl, -(CH2)o-N-(lower alkyl)2, (CH2 )p-cycloalkyl, (CH2)p-heterocycloalkyl, (CH2)p-aryl, (CH2)p-heteroaryl, which rings may be substituted by R, or R1 and R2 may form together with the N-atom to which they are attached a heterocyclic ring, optionally with further ring-heteroatoms selected from N, O or S, which ring may be substituted by R; R is halogen, lower alkyl, lower alkyl substituted by halogen, lower alkoxy or lower alkoxy substituted by halogen; R3 is hydrogen or lower alkyl; n is O, 1, 2, 3 or 4; o is 1, 2 or 3; P is 0, 1 or 2; or to pharmaceutically suitable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. It has been found that the compounds of formula I are orexin receptor antagonists and the related compounds may be useful in the treatment of disorders, in which orexin pathways are involved like sleep disorders. |