| abstract |
The subject of the present invention is compounds corresponding to formula (I) wherein: X represents a divalent radical (C1-C5) unsubstituted or substituted alkylene; R1 represents: a group -NR8R9; a piperidin-4-yl radical or a piperidin-3-yl radical unsubstituted or substituted; R2 represents a halogen atom, an Alk group, an OAIk group; R3 represents a methoxy; R4 represents a hydrogen atom, a halogen atom, an Alk group, a hydroxy, an OAIk group; R5 represents an atom hydrogen, a halogen atom, an Alk group, a hydroxy, an OAlk group, a -CO2Alk group, a -CH2OH radical; R6 represents a hydrogen atom, an Alk group, a hydroxyl, an OAlk group, a (C3-C5) cycloalkyoxy, a group -NRIQCONRI 1R12; R7 represents a hydrogen atom, a halogen atom, a AIk group, hydroxy, OAIk group; or well R7 is in position -3- phenyl and together with R6 they represent a trimethylene radical; R8 and R9 represent each independently a hydrogen atom or a (C1-C4) alkyl; or R8 and R9 together with the nitrogen atom to which they are linked constitute an unsubstituted or substituted heterocyclic radical; R10 represents a hydrogen atom or a (C1-C4) alkyl; R11 and R12 each independently represent a hydrogen atom or a C4) alkyl; Alk represents a (C1-C4) alkyl not substituted or substituted one or more times with a fluorine atom. Process of preparation and application in therapy. |