| abstract |
Fusion polypeptides, and methods for producing thereof, said fusion polypeptides comprising a first polypeptide and a second polypeptide, said second polypeptide comprises consecutive amino acids which ( i) are identical to a stretch of consecutive amino acids present in a chain of an Fc domain of an antibody; (ii) bind to an Fe receptor; and (iii) have at their N-terminus a sequence selected from the group consisting of a cysteine, selenocysteine, CP, CPXCP (where X = P, R, or S), CDKTHTCPPCP, CVECPPCP, CCVECPPCP and CDTPPPCPRCP, said first and second polypeptide are linked by a chemical structure, said first polypeptide is linked to said chemical structure by a nonpeptidyl linkage; said second polypeptide is linked to said chemical structure by a peptidyl linkage. |