| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_76ba102ea9c02b6633d64bf09c5b89a4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2e3830f35387a1c32061dea3ee310851 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5063
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1664
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-15001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0053
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-4813
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K36-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K36-23
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K36-31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-485
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8214
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8257
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-164
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-65
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6415
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-17023 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-82
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-04 |
| filingDate |
2014-10-20^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2022-07-05^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e293758f5038ec22862b572ec96bb344
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8c703698022706ded30ae5b549ae8318
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7acd4a46f0cb29226a4f480d3d047f7c |
| publicationDate |
2022-07-05^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CA-2957211-C |
| titleOfInvention |
Oral delivery of angiotensin converting enzyme 2 (ace2) or angiotensin-(1-7) bioencapsulated in plant cells |
| abstract |
Low activity of angiotensin converting enzyme2 (ACE2) and its product, angiotensin-(1-7) [Ang-(1-7)] appear to contribute to pulmonary hypertension (PH). Long-term delivery of ACE2 or Ang-(1-7) require stability and ease of administration to increase patient compliance. Chloroplast expression of therapeutic proteins enables their bioencapsulation within plant cells to protect from acids and gastricenzymes and to facilitate absorption. Rats fed with bioencapsulated ACE2 or Ang-(1-7) exhibited improved heart function. A combination of ACE2 and Ang-(1-7) augmented the beneficial effects. Experiments indicate that this method is suitable for the treatmen or inhibition of experimental uveitis and autoimmune uveoretinitis These studies provide proof-of-concept for transplastomic technology as a novel low-cost oral ACE2 or Ang-(1-7) delivery system. |
| priorityDate |
2013-10-18^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |