| abstract |
The present invention relates to an SIRT 1 activator and a medicinal use thereof. Prepared in the present invention is a novel SIRT 1 activator compound based on a benzo[d]furan or benzo[d]oxazole framework, a crystalline form thereof, a hydrate thereof, or a salt thereof, and the compound was found to have the effects of alleviating obesity, insulin resistance, and dyslipidemia; protecting against cellular senescence and oxidative stress and prolonging the life of yeasts; and promoting collagen synthesis and reducing wrinkles. Therefore, the novel SIRT 1 activator compound having the above effects can be used in a pharmaceutical composition for preventing or treating metabolic diseases including obesity, diabetes, dyslipidemia, etc., and liver diseases including alcoholic or non-alcoholic fatty liver, steatohepatitis, etc., in a cosmetic composition for preventing or reducing wrinkles, and in a health food composition for alleviating cellular senescence or prolonging the life of cells. |