| abstract |
Substd. 2,3,4,5-tetrahydro-1H-3-benzazepins (I) and their acid addition salts possess anorexigenic properties and are intermediates for antihypertensive N-guanidino-alkyl derivs. and for hypoglycaemic arylsulphonyl-ureas. Prepn. is by reaction of phenylethylamine derivs. (II) with a Lewis acid e.g., alCl3 at 100-300 degrees and converting the isolated product if required to an acid addition salt (II) are prepd. by reacting ethylenimine and styrene in the presence of metallic Na to give Ph-aziridinyl-ethane derivs., converting these to phenylethylamine derivs. and cyclising these with acid to give (I). |