http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101235031-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_20f2cf46e198d06d0a526e19d2dbfa9a |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 |
| filingDate | 2008-03-07^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a225c944c5245b262ab778a41ce46d19 |
| publicationDate | 2008-08-06^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-101235031-A |
| titleOfInvention | Oriented synthesis and crystal structure of 21(S) argatroban, and preparation for monohydrate thereof |
| abstract | The invention relates to a 21(S) argatroban rational synthesis method, a corresponding crystal structure and a hydrate preparation method, wherein the rational synthesis uses (3S)-1, 2, 3, 4-tetrahydrochysene-3-methyl-8-quinolinesulfonyl chloride as raw material to prepare single diastereoisomer 21(S) argatroban, and uses single crystal and polycrystalline powder X diffraction method to determine the absolute configuration as 21(S) and the crystal systems I, II, and the 21(S) argatroban is soluble in hot water, via controlling the cooling speed, a 21(S) argatroban hydrate is prepared. Animal tests prove that the anticoagulant function of the 21(S) argatroban hydrate is 2-3 powers of 21(R) argatroban hydrate. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2752412-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101519429-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105367622-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104558103-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012136504-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10385020-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9994526-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104558103-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IT-MI20110545-A1 |
| priorityDate | 2008-03-07^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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