| abstract |
The compounds of the present invention find use in the treatment of mammalian cancers, especially human cancers, including but not limited to malignant melanoma, solid tumors, glioblastoma, ovarian cancer, pancreatic cancer, prostate cancer , Lung cancer, Breast cancer, Kidney cancer, Liver cancer, Cervical cancer, Metastasis of primary tumor site, Myeloproliferative disorders, Chronic myelogenous leukemia, Leukaemia, Papillary thyroid carcinoma, Non-small cell lung cancer, Mesothelioma, Hypertropia Eosinophilic granulocytic syndrome, gastrointestinal stromal tumors, colon cancer, eye diseases characterized by hyperproliferation leading to blindness (including multiple retinopathy, diabetic retinopathy), rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, mast cell hyperlipidemia, mast cell leukemia, and oncogenic forms, aberrant fusion proteins, and Diseases caused by polymorphic forms. |