http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102417479-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ac31afbea1cbbb03498644721ffb4a62 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 |
| filingDate | 2011-08-29^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1c3be62ffef491787b3fda54a155aa16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_38b275682fd9af41be9a97acfe9674bf |
| publicationDate | 2012-04-18^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102417479-A |
| titleOfInvention | STAT3 small molecule selective inhibitor and its preparation method and application |
| abstract | The invention discloses a small molecule selective inhibitor of STAT3 and its preparation method and application. The small molecule selective inhibitor of STAT3 includes four general structural formulas of formula I, formula II, formula III and formula IV. The preparation comprises: reacting 2-phenyl substituted quinoline-4-carboxylic acid with thionyl chloride or oxalyl chloride to generate a substituted acid chloride, and then reacting with a substituted aromatic amine to generate a substituted quinoline-4-amide derivative. The application is in the preparation of cancer drugs related to the abnormally activated STAT3 pathway and in the preparation of anti-tumor drugs as STAT3 signaling pathway inhibitors. The STAT3 inhibitor of the present invention is a class of small-molecule selective inhibitors. As a result of evaluating its activity by measuring its effect on cancer cells, it can be concluded that the small-molecule STAT3 selective inhibitor of the present invention can be used for related cancer treatment The development of drugs has a wide range of uses and good medical efficacy. The small-molecule STAT3 selective inhibitor of the invention has many types, easy-to-obtain raw materials, simple preparation method, high product purity, high yield and strong practicability. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023077739-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109369627-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113845476-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110105279-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108084088-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109180657-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109336868-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108084088-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104725480-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109485643-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109293641-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104693280-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112703001-A |
| priorityDate | 2011-08-29^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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