http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102639496-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e459b6d9cc66efbd6417c94813588e27 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-02 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-095 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D241-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C217-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C323-25 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4965 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C217-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C211-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-095 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C321-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-35 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C43-115 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-04 |
| filingDate | 2010-04-19^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_09d5b38faf62418eb6f8fe13f9f1da83 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_75d52ab8711f65ab81652888e2776e2e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6f589e218556d7f728ad4b0e6109706f |
| publicationDate | 2012-08-15^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102639496-A |
| titleOfInvention | Lysine specific demethylase-1 inhibitor and its application |
| abstract | The present invention relates to compounds of formula (I): (A') x -(A)-(B)-(Z)-(L)-(D), wherein: (A) is heteroaryl or aryl; each (A'), if present, are independently selected from aryl, aralkoxy, aralkyl, heterocyclyl, aryloxy, halo, alkoxy, haloalkyl, cycloalkyl, haloalkoxy group, and cyano group, wherein each (A') is substituted by 0, 1, 2, or 3 substituents independently selected from halo, haloalkyl, aryl, aralkoxy, alkane group, alkoxy, cyano, sulfonyl, amido, and sulfinyl; X is 0, 1, 2, or 3; (B) is a cyclopropyl ring, where (A) and (Z) are covalent bonded to a different carbon atom of (B); ( Z ) is -NH-; ( L ) is selected from -CH2CH2- , -CH2CH2CH2- , and -CH2CH2CH2CH2 -; and (D) are selected from the group consisting of -N(-R 1)-R2, -O-R3, and -S-R3, wherein: R1 and R2, together with the nitrogen atom to which R1 and R2 are attached, are linked together to form a heterocyclic ring , wherein the heterocycle has 0, 1, 2, or 3 substituents independently selected from -NH 2 , -NH(C 1 -C 6 alkyl), -N(C 1 -C 6 Alkyl) (C 1 -C 6 alkyl), alkyl, halo, cyano, alkoxy, haloalkyl, and haloalkoxy, or R1 and R2 are independently selected from -H, alkyl, cycloalkane group, haloalkyl, and heterocyclyl, wherein the total number of substituents on R1 and R2 together is 0, 1, 2, or 3, and the substituents are independently selected from -NH 2 , -NH(C 1 -C 6 alkyl), -N(C 1 -C 6 alkyl) (C 1 -C 6 alkyl), and fluoro; and R3 is selected from -H, alkyl, cycloalkyl, haloalkyl, and Heterocyclyl, wherein R3 has 0, 1, 2, or 3 substituents independently selected from -NH 2 , -NH(C 1 -C 6 alkyl), -N(C 1 -C 6 Alkyl) (C 1 -C 6 alkyl), and fluoro; or enantiomers, diastereomers, or mixtures thereof, or pharmaceutically acceptable salts or solvates thereof. The compounds of the present invention exhibit inhibitory LSD1 activity which makes them useful for the treatment or prevention of diseases such as cancer. |
| priorityDate | 2009-09-25^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006148904-A1 |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID466655554 |
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