http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102702060-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0b03ed3da9103d5f4afdf6dd60551aec http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d40285e27f4ed83b8728b0d477404958 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-53 |
| filingDate | 2012-05-25^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-01-29^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a7405f57ad76f71c5a92b8eaadbcce9b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1abd1938c0a8b9f545e3260381fbe204 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_22553e8bbc3f39c453ab44afb25c7d33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a26c7ba230bbcb956f43a2ee7d2853bb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e74a64f999f7e7a38ae9e9cc531ee044 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a9fd03e7ef7d7b2eed5bb363cacafd1 |
| publicationDate | 2014-01-29^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102702060-B |
| titleOfInvention | Racemization recovery method for by-products in split mother liquor of Vernakalant intermediates |
| abstract | The invention discloses a racemization recovery method for by-products in split mother liquor of Vernakalant intermediates, wherein the racemized Vernakalant intermediates that are 2-((R)-3-(aromatic methoxyl)-1-pyrrolidyl)cyclohexanol are processed through chemical resolution for preparing mother liquor with RRR configurations, and the mother liquor with RRR configurations is purified; SSR configurations that are obtained through recovery are taken as reaction substrates, react with dichloro triaryl phosphines in alkaline substances for 1 to 5 hours under the temperature ranging from 40 to 100 DEG C; then water is added, and the reaction along with stirring is performed for 1 to 5 hours under the temperature ranging from 40 to 100 DEG C; then liquid reactant is processed through pH adjustment to obtain racemized products that contain the RRR configurations and the SSR configurations and are formed by a pair of diastereoisomers, and triaryl phosphine oxides are obtained through recovery at the same time; and in addition, the diastereoisomers are repeatedly split and salified so as to prepare final chiral products. By adopting the racemization recovery method, waste mother liquor is converted to the products, waste is changed into valuable, yield coefficient is improved greatly, the triaryl phosphine oxides can be recycled, the manufacturing cost is lowered, the environmental protection problem of treatment of split mother liquor can be solved, and the economical benefits and the social benefits are obvious. |
| priorityDate | 2012-05-25^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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