http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102869258-A

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publicationDate 2013-01-09^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-102869258-A
titleOfInvention Dihydropyridophthalazinone inhibitors of poly(ADP-ribose) polymerase (PARP) for the treatment of diseases associated with PTEN gene deletion
abstract A compound having a structure shown in formula (I) and formula (II): , wherein the substituents Y, Z, A, B, R 1 , R 2 , R 3 , R 4 and R 5 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose) polymerase activity. Also described herein are pharmaceutical compositions containing at least one compound described herein and the use of the compounds or pharmaceutical compositions described herein in the treatment of diseases, disorders and conditions associated with PTEN loss that are ameliorated by inhibition of PARP activity.
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priorityDate 2010-02-03^^<http://www.w3.org/2001/XMLSchema#date>
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