http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103059016-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4738 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D455-03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-147 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4375 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4375 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D455-03 |
| filingDate | 2012-10-24^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-09-14^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-09-14^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103059016-B |
| titleOfInvention | Coptisine derivatives, its synthetic method and anti-tumor drug purposes thereof |
| abstract | The invention discloses coptisine derivatives, its synthetic method and anti-tumor drug purposes thereof.Described coptisine derivatives is that 3 aliphatic groups as shown in formula 1 replace coptisine derivatives or its physiologically acceptable salt, and this compound obtains through derivative reaction with hydrochloric acid coptisine for substrate.Described coptisine derivatives or its physiologically acceptable salt are respectively provided with significant cytotoxic activity, part of compounds activity is apparently higher than substrate hydrochloric acid coptisine, or quite or it is higher than positive control medicine with positive control medicine, can be used for preparing the medicine for the treatment of malignant tumor. Wherein, R 1 Selected from hydrogen or alkyl, described alkyl is C n H 2n+1 Or C m H 2m‑1 , n is selected from the integer of 1 19, and m is selected from the integer of 1 19. |
| priorityDate | 2011-10-24^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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