http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104147616-B
Outgoing Links
Predicate | Object |
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classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
filingDate | 2014-08-06^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2018-03-02^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2018-03-02^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-104147616-B |
titleOfInvention | The application of double-stranded RNA or its trim in tumor inhibitor is prepared |
abstract | The invention discloses the application of double-stranded RNA or its trim in tumor inhibitor is prepared.The application of double-stranded RNA provided by the present invention or its trim in tumor inhibitor is prepared, a chain-ordering of the double-stranded RNA is SEQ ID No.1 in sequence table, and another chain-ordering of the double-stranded RNA is SEQ ID No.2 in sequence table;The trim of the double-stranded RNA is by following A 1) or A2) or A3) the obtained double-stranded RNA trim of modification:A1) 2 ' OH of the ribose of the double-stranded RNA are modified;A2) phosphodiester bond of the connection nucleotides to the double-stranded RNA is modified;A3 the modification of cholesterol) is connected to 5 ' ends of the ribose of the double-stranded RNA.It is demonstrated experimentally that 2 ' OMe the dsRNA21 of the application or its trim can effectively suppress tumour and tumour cell. |
priorityDate | 2014-08-06^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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