| abstract |
The present invention relates to ingenol-3-acylate III and ingenol-3-carbamate; specifically; the present invention relates to individually or apply in the treatment with one or more other medicines active compound, for preventing, treat or improving, the stimulation of centering granulocyte oxidative burst has response, the stimulation of Human Keratinocytes IL-8 release has response or to the necrosis induced disease having response or the compound of Formula I of situation, its officinal salt, hydrate or solvate, wherein R is the heteroaryl optionally replaced by R7；Or R is Heterocyclylalkyl or heterocycloalkenyl, it is optionally replaced by R8；Or R is X, wherein X is NR11R12. |