| abstract |
The invention discloses the application of a naphthalene-1,4-dione compound as an hCBS enzyme inhibitor, in particular to the compound 2-chloro-3-(4-methylpiperidin-1-yl)naphthalene-1,4 - Use of diketones as hCBS enzyme inhibitors. The IC 50 of the small molecular compound on the hCBS enzymatic reaction in vitro is 20 μM. The small molecular compound can be used as a tool drug for studying H 2 S signaling pathways, and a lead compound for developing drugs for treating circulatory shock, stroke, Down syndrome and tumors and other diseases related to H 2 S. |