http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104784183-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2015-02-04^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-09-07^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-09-07^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104784183-B |
| titleOfInvention | A small molecule inhibitor and its application in inhibiting S-adenosylmethionine decarboxylase |
| abstract | A small molecule inhibitor, the structural formula of the small molecule inhibitor is The inhibitor also includes pharmaceutically acceptable salts containing the chemical structure shown in general formula I, wherein R 2 includes =O, -NH 2 , -CH 2 (NH 2 ), -C(NH 2 ) 3 , Any one of ‑CO(NH 2 ), ‑CH 2 ‑CHO. The present invention uses the small molecule inhibitor to inhibit S-adenosylmethionine decarboxylase. The present invention uses AutoDockVina software to dock small molecules composed of the above-mentioned skeleton and substituents into the determined AdoMetDC pocket, and evaluates the scores given by the AutoDockVina software, and the small molecules with the lowest scores lower than -7.0 are used for experimental verification. |
| priorityDate | 2015-02-04^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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