http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104826139-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-14 |
| filingDate | 2015-05-04^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-01-02^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-01-02^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104826139-B |
| titleOfInvention | A kind of preparation method of the extra small ferroso-ferric oxide MRI positive nano-probes of rgd peptide targeting |
| abstract | The present invention relates to a kind of preparation method of the extra small ferroso-ferric oxide MRI positive nano-probes of rgd peptide targeting, including：The stable extra small Fe of surface sodium citrate is obtained through a step solvent structure 3 O 4 Nano particle, then by NH 2 Nano grain surface is arrived in PEG RGD modifications, obtains the extra small ferroso-ferric oxide MRI positive molecular probes of RGD targetings.The extra small ferriferrous oxide nano probe for having modified PEG RGD has the long circulating time in Mice Body, and is realized in cellular level and animal level to surface α v β 3 The high expression cancer cell (U87MG cells, human glioma cell) of integrin and the targeting T of subcutaneous transplantation knurl 1 Weight Contrast-enhanced MRI.Fe prepared by the present invention 3 O 4 Nano particle can long-time stable be scattered in the aqueous solution, be not in agglomeration.Preparation method of the present invention is simple, and cost is low, has industrialization and commercialization potential. |
| priorityDate | 2015-05-04^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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