| abstract |
The invention discloses a pH-responsive/membrane-adhesive bifunctional amphiphilic block copolymer and a preparation method thereof. Methacrylic acid with an isoelectric point of 5.0-6.5 is used as a pH-responsive monomer, and pH-insensitive hydrophilic Aminoethyl methacrylate is a membrane-adhesive monomer. Electron transfer activator regeneration-atom transfer radical living polymerization method is used to prepare a block copolymer of pH-responsive monomer and hydrophobic monomer. This is a macromolecular initiator, and then polymerizes the membrane-adhesive monomer aminoethyl methacrylate, and finally undergoes an acid hydrolysis reaction to prepare a pH-responsive/membrane-adhesive amphiphilic block copolymer. The block copolymer can self-assemble in aqueous solution to form a core-shell structure micelle, which has good pH sensitivity and membrane adhesion, low critical micelle concentration, small micelle particle size, and can be used for polypeptide or protein Drug delivery system for drug-like oral therapeutic applications. |