http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106854202-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D407-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D407-04 |
| filingDate | 2016-12-05^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-11-13^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-11-13^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106854202-B |
| titleOfInvention | Novel method for preparing pranlukast high-purity asthma medicine |
| abstract | The invention discloses a novel method for preparing pranlukast high-purity asthma medicine, which relates to the technical field of medicine organic synthesis, and is characterized in that 8-amino-4-oxo-2-tetrazole-5-yl-4H-1 benzopyran hydrochloride is used as a reaction raw material, and is subjected to neutralization and salification reaction with an alkaline substance to generate an intermediate, and the obtained intermediate is subjected to amidation reaction with p-phenylbutoxy benzoyl chloride in a non-polar solvent to obtain the pranlukast. The whole process is simple, clean and easy to control, so that the purity of the obtained crude product can reach more than 99 percent, and the purity of the crude product can reach more than 99.9 percent after one-time purification. |
| priorityDate | 2016-12-05^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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