| abstract |
The invention discloses a spiro[3,5'-pyrrole[2,1-a]isoquinoline-oxindole] compound, which comprises adding 3-pyrrole-oxindole and 2-bromomethyl to an organic solvent Aryl bromide, then add metal palladium catalyst, phosphine ligand and inorganic base, carry out chemical reaction under heating conditions, after the reaction is completed, the pure product of the compound of the present invention is obtained after treatment, and the preparation method is as follows: The preparation method of the present invention uses the easy-to-prepare 3-pyrrole oxindole and the commercially available 2-bromomethylaryl bromide as raw materials, through a one-pot method of nucleophilic substitution/C(sp 2 )-H arylation A series of spiro[3,5'-pyrrole[2,1-a]isoquinoline-oxindole] compounds with novel and diverse structures were obtained by cascade reaction, which has a wide range of substrates, easy operation and simple post-treatment and higher yields. |