abstract |
The present invention discloses carboxamide compounds as well as pharmaceutical compositions and methods of use. One embodiment is a compound having structure (I), wherein R 1 , R 2 , R 3 , R 4 , D, J, Z, T, p, q, w and x are as described herein. In certain embodiments, the compounds disclosed herein activate AMPK channels, and are useful in the treatment of metabolic-related disorders and conditions. |